Heterogeneity within MDD has hampered identification of biological markers (e.g., intermediate phenotypes, IPs) that might increase risk for the disorder or reflect closer links to the genes underlying the disease process. The newer characterizations of dimensions of MDD within Research Domain Criteria (RDoC) domains may align well with the goal of defining IPs. We compare a sample of 25 individuals with MDD compared to 29 age and education matched controls in multimodal assessment. The multimodal RDoC assessment included the primary IP (...) biomarker, positron emission tomography (PET) with a selective radiotracer for 5-HT1A ([11C]WAY-100635), as well as event-related functional MRI with a Go/No-go task targeting the Cognitive Control network, neuropsychological assessment of affective perception, negative memory bias and Cognitive Control domains. There was also an exploratory genetic analysis with the serotonin transporter (5-HTTLPR) and monamine oxidase A (MAO-A) genes. In regression analyses, lower 5-HT1A binding potential (BP) in the MDD group was related to diminished engagement of the Cognitive Control network, slowed resolution of interfering cognitive stimuli, one element of Cognitive Control. In contrast, higher/normative levels of 5-HT1A BP in MDD (only) was related to a substantial memory bias toward negative information, but intact resolution of interfering cognitive stimuli and greater engagement of Cognitive Control circuitry. The serotonin transporter risk allele was associated with lower 1a BP and the corresponding imaging and cognitive IPs in MDD. Lowered 5HT 1a BP was present in half of the MDD group relative to the control group. Lowered 5HT 1a BP may represent a subtype including decreased engagement of Cognitive Control network and impaired resolution of interfering cognitive stimuli. Future investigations might link lowered 1a BP to neurobiological pathways and markers, as well as probing subtype-specific treatment targets. (shrink)

Anlatımda yoğunluk, özne ile yüklem arasına bir takım unsurların ek-lenmesiyle başlar. Yüklemin anlamı çeşitli açılardan bütünlenir, belirgin kılı-nır ya da pekiştirilir. Bunun için sözcüklere ya da sözcelere başvurulur. Türkçe cümlede, yüklemcil öğeyi çeşitli açılardan tamamlama görevi üstlenmiş cümle öğesi olarak tarif edilen tümleç, eylemin gösterdiği iş, oluş vb.’lerini tamamlama işlevi nedeniyle böyle adlandırılmıştır. Arapçada cümledeki bütün öğeleri içeren iki temel kavram vardır: ıtlâk ve takyîd. Itlak kavramı, özne ve yüklemi ifâde eden temel öğelerdir. Takyîd ise, cümlenin müsned ve müsnedün ileyh (...) ile tamamlanmayıp mefuller, tâbiler, fasl zamiri, nevâsıh, şart edatları, nefy edatları, hâl ve temyiz gibi diğer öğelere de duruma göre ihtiyaç duymasıdır. Türkçe cümlede tümlece karşılık olarak geldiği düşünülen meful çeşitlerini ve karşılıklarının incelendiği makalede mef‘ûlu bih, mef‘ûlu mutlak, mef‘ûlu lieclih, mef‘ûlu me‘ah, mef‘ûlu fih olmak üzere beş meful çeşidi ele alınmıştır. Arapça cümledeki mef‘ûlu bihe karşılık olarak Türkçe cümlede nesne ve düz tümleç, Arapça cümledeki mef‘ûlu mutlaka karşılık olarak Türkçe cümlede kökteş tümleç, Arapça cümledeki mef‘ûlu lieclihe karşılık olarak Türkçe cümlede sebep tümleci, Arapça cümledeki mef‘ûlu me‘aha karşılık olarak Türkçe cümlede beraberlik tümleci, Arapça cümledeki mef‘ûlu fihe karşılık olarak Türkçe cümlede zarf tümlecinin bulunduğu ifade edilebilir. (shrink)

Güzellik ve sanat iç içe geçmiş iki kavramdır. Bir bakıma güzellik, sanatın özüdür denilebilir. Her sanat dalında olduğu gibi hat sanatında da güzeli arama arzusu ve eşsiz eserler ortaya koyma çabası, hattatları sabırla çalışmaya ve kendi sınırlarını zorlamaya sevk etmiştir. Bir kitap sanatı olan hüsn-i hattın kelime manasının “güzel yazı” olmasına mukabil, daha iyisini yazmak uğruna harcanan çaba yorucu ve zahmetlidir, ancak sabırla çalışan elbette ki karşılığını alır. Başka bir deyişle “Muhakkak ki Allah güzeldir, güzeli sever!” hadis-i şerifi ışığında bu (...) sanata gönül verenler, yazıyı daha muntazam yazma hususunda büyük ölçüde gayret gösterirler. Kişinin muntazam yazmayı başarması ise, sistematik çalışmasına bağlıdır. Yazıyı kaidelerine uygun ve ölçülü yazabilmek bıkmadan usanmadan, karamsarlığa kapılmadan çalışmakla mümkündür. Bu sebeple gerek öğrenme aşamasında ve gerekse sonrasında, harfler defalarca çalışma kâğıdına yazılarak el melekesi artırılır. Kelimeler ve harfler kâğıda kimi zaman noktalanıp ölçülendirilerek, kimi zaman da noktalanmadan yazılır. Talim amaçlı yapılan bu çalışmalar, başka bir deyişle karalamalar, hat sanatının temeli niteliğindedir. Arap alfabesiyle yazılan ve “karalama” adı verilen el alıştırmaları yazıyla uğraşan kişinin o an irticalen elinden çıkan harf veya kelimelerden oluşur ve çoğu zaman bir anlam ifade etmez. Bu çalışmanın amacı, karalamaların estetik unsurlarını ele almak ve zaman içerisinde uğradığı değişime mercek tutmaktır. Hattatların bu özgür yorumları gün geçtikçe daha fazla önemsenmekte ve hayranlık uyandırmaktadır. Harf bünyesini oluşturan kaidelerin dışında satır ve sınırlara bağlı kalmadan yazılan bu yazılar kendi içinde bir kompozisyon oluşturmakta ve çoğu zaman yazan kişiyi dahi hayrete düşürecek özgün çalışmalar ortaya çıkabilmektedir. (shrink)

Bu çalışmanın amacı Martin Buber etiğinin özgünlüğünü keşfetmek ve geliştirmektir. Buber varlığı ilişki temelinde ele alarak Ben-O ve Ben-Sen ilişkisi olarak ayırmıştır. Ben-O ilişkisi insanın varlıkla sıradan tecrübesine karşılık gelirken, Ben-Sen ilişkisi insanın ötekiyle diyalog kurduğu anda ortaya çıkan daha derin bir ilişkidir. Ötekiyle ilişki; tüm etik değerlendirmeleri içinde barındıran, yaşamın dinamizmine uygun, insanlık tarihinin mitolojik ve etik dinamiklerini de içeren bir ilişkinin temellerini içermektedir. Ben-Sen ilişkisi yalnızca insanın insanlarla kurduğu bir ilişkiyi değil insanın canlı, cansız ve manevi tüm varlıklarla (...) kurduğu ilişkiyi açıklamaktadır. Ben-Sen ilişkisinin sadece insanın insanla olan ilişkiyi ele almaması etik üzerine yapılan çalışmalara yeni bir bakış sağlayacak niteliktedir. Buber’in etik anlayışı; diyalog etiği, ötekiyle ilişki etiği, durum etiği, antropolojik etik, varoluş etiği, meslek etiği, anarşist etik, postmodern etik gibi birçok etik anlayışla bağlantılıdır. Buber herhangi bir ahlaki norm ve etik koda bağlı olmayan, tarihsel, ontolojik ve ilişkiyi öncül kılan geniş çaplı içeriğe sahip bir etiğin temellerini ortaya koymaktadır. (shrink)

Tefvîz meselesi ictihada başvurmaksızın ilkten hüküm koyma esasına dayanan girift bir meseledir. Şer’î ahkâmın kaynağı ya vahiy veya vahyin ışığında ictihaddır. Tefvîzde ise hüküm herhangi bir vahiy veya ictihada dayanmayıp, Allah tarafından daha önce verilen yetkiye dayanmaktadır. Tefvîzde ilkten ve re’sen bir hüküm koyma söz konusudur. Usulcüler arasında böyle bir yetkinin imkanı tartışılmış, mesele etrafında kabul ve red şeklinde temel iki görüş ortaya çıkmıştır. Bu ihtilafın temelinde hüsün ve kubuh etrafındaki kelamî tartışmaların önemli rol oynadığı anlaşılmaktadır. Tefvîzi kabul eden usulcüler (...) kendi içerisinde aklen cevaz verenler; hem aklen hem de fiilen mümkün görenler şeklinde ayrışmışlardır. Kabul eden usulcüler detayda da ihtilaf etmişler kimi usulcüler tefvîze peygamber, müctehid/âlim ve hatta âmmî bakımından cevaz verirken, kimisi sadece peygamber bakımından, kimisi hem peygamber hem de müctehidler bakımından cevazına hükmetmişlerdir. Çoğunluğu Mu‘tezile mensubu olan usulcüler ise ne aklen ne de fiilen gerçekleşmesini mümkün görmemişlerdir. Hem aklen hem de fiilen cevaz veren ve tefvîzi peygamber ve âlimlere teşmil eden usulcüler arasında Mu’tezilî âlim Müveys b. İmrân’ın adının ön plana çıktığı görülmektedir. İmam Şâfiî ve Şâfiî usulcüler de aynı grup içerisinde yer almış olmakla birlikte özellikle İmam Şâfiî’nin görüşü noktasında net bilgiler sunulamamıştır. Hem aklen hem de fiilen gerçekleştiğini kabul eden usulcüler görüşlerini aklî ve sem’î delillerle temellendirmeye çalışmışlardır Tefvîze cevaz veren usulcüler ayrıca tefvîzi şer’î hükmün kaynaklarından biri olarak kabul etmişlerdir. Tefvîze cevaz vermeyen ve çoğunluğunu fukahâ/Hanefî metoduna mensup alimlerin oluşturduğu usulcüler ise şer’î hüküm kaynaklarının vahiy ve ictihad olduğuna vurgu yaparak peygamber de olsa bunların dışında başka bir teşrî’ kaynağı bulunamayacağını iddia etmişler, onlar da iddiaların aklî ve naklî delillerle gerekçelendirmeye çalışmışlardır. Şîî usulcüler arasında tefvîzi temelden reddedenler olduğu gibi kabul ve red şeklinde sünnî usulcülerle benzer yaklaşımlar sergileyen alimler de bulunmaktadır. Bazı aşırı Şîa fırkaları arasında tekvînî tefvîz denen bir anlayış da bulunmaktadır. Bu anlayışa göre âlemin yaratılması, idare edilmesi, öldürme, diriltme, rızık verme, âhirette ceza ve mükâfat verme gibi hususlar Allah tarafından Hz. Peygamber, Hz. Ali ve imamlara havale edilmiştir. Fakat bu anlayış mutedil Şîa alimleri tarafından şiddetle reddedilerek bunu savunanların küfrüne hükmedilmiştir. Kimi usulcülerin ictihadla tefvîzi birbirine karıştırdıkları veya en azından tefvîzi de ictihad kapsamında gördükleri anlaşılmaktadır. Oysaki tefvîzin en temel özelliklerinden biri ictihada başvurmadan hüküm vermektir. Dolayısıyla böyle bir yaklaşım isabetli gözükmemektedir. (shrink)

This paper explores the complex relationship between intellectual property (IP) and the transdisciplinary collaborative design (co-design) of new digital technologies for agriculture (AgTech). More specifically, it explores how prioritizing the capturing of IP as a central researcher responsibility can cause disruptions to research relationships and project outcomes. We argue that boundary-making processes associated with IP create a particular context through which responsibility can, and must, be located and cultivated by researchers working within transdisciplinary collaborations. We draw from interview data and (...) situated IP practices from a transdisciplinary co-design project in Aotearoa New Zealand to illustrate how IP is a fluid boundary-requiring-and-producing object that impels researchers into its management, and produces tensions that need to be noticed and skillfully navigated within research relations. We propose located response-ability as a conceptual tool and practice to reposition IP within the relations that make up a transdisciplinary co-design project, as opposed to prioritizing IP by default without recognizing its possible impacts on collaborative relations and other project aims and accountabilities. This can support researchers practicing responsible innovation in making everyday decisions on how to protect potential IP without disrupting the collaborative relations that make the creation of potential IP possible, and the existence of protected IP relevant and beneficial to project collaborators and wider societal actors. This may help to ensure that societal benefits can be generated, and positive science–society relationships prioritized and preserved, in the design of new AgTech. (shrink)

And in this book the distinguished scholar Amartya Sen offers a powerful critique of the theory of social justice that, in its grip on social and political ...

"Ever since the explosion in relationships of power during the 1960s, the humanities have become a battlefield. What had previously been thought of as merely academic concerns have spilled over academic boundaries and attracted the attention of politicians, government officials, members of the media, and, ultimately, the general public. As a way of addressing this turmoil, Karlis Racevskis considers the legacy of the Enlightenment and revaluates modernity's claims for objective knowledge and the traditional model of reason. How relevant, he asks, (...) are the Enlightenment ideals of freedom, democracy, and equality in today's attempts to understand society and gauge the prospects for civilization? What responsibility can or should intellectuals assume in promoting Enlightenment values? What, in the end, constitutes a humanistic education?" "Drawing largely on the work of Foucault, Racevskis elucidates the philosophical and political problems at issue in the debate and the changes taking place in our ways of seeing ourselves and our relations with others. He shows how the theme of enlightenment has been a central component in the conflicts that pit modernists against postmodernists, Marxists against post-Marxists, and liberals against conservatives, and he juxtaposes the arguments in such a way as to place reason and enlightened action in a new perspective. One result of the upheaval, argues Racevskis, is a sense of renewed purpose and intensity in the study of the humanities that constitutes a fundamental reorientation in our ways of understanding society. Viewing the tension between the chaos of current theories and the comfort of traditional values, not with horror but with excitement, he suggests how postmodern criticism can be seen as a dynamic and promising development in the renewal and expansion of the liberal arts." "This wide-ranging book should have general appeal across a broad spectrum of disciplines-among them, literature and the arts, philosophy, social and political theory, and intellectual history."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved. (shrink)

Transcripts of papers presented at a national seminar sponsored by Indian Council of Philosophical Research.

I am most grateful to Elizabeth Anderson (2000), Philip Pettit (2000) and Thomas Scanlon (2000) for making such insightful and penetrating comments on my work and the related literature. I have reason enough to be happy, having been powerfully defended in some respects and engagingly challenged in others. I must also take this opportunity of thanking Martha Nussbaum, for not only chairing the session in which these papers were presented followed by a splendid discussion (which she led), but also for (...) taking the initiative, in the first place, to arrange the session. (shrink)

In this book a comprehensive study of the theories of error in classical Indian philosophy has been made by applying the techniques of linguistic and conceptual analysis. The special feature of this volume is that the different tools of analysis are directly applied on the classical Indian arguments. By way of analysis, it is maintained that the Indian theories of error are neither advancing a psychological account of error nor are the theories advancing any metaphysical theory regarding the ontological status (...) of the object of error but are primarily engaged in unravelling the logical structure of the concept of error. It is held in this work that the Khyativadas are theories about the logical nature or erroneous about the ontological status of the object. (shrink)

The Iranian government is a theocracy—the only one in the world today. The clergy control all three branches of government. The supreme leader or velayat-e-faqu’ih is also a cleric. In such a political system all legislation and policy making are conducted in accordance with the leaders’ interpretation of Islamic law or Shari’a. In this paper I will examine the extent to which these laws and policies allow the government to intrude into the private sphere of life and intervene in the (...) privacy of individual citizens. I will use specific examples to illustrate my point that since citizens have no control over their government and cannot impact the interpretation of Shari’a, their private sphere is always threatened by government action. (shrink)

Illustrations: 1 B/w Illustration Description: Pranab Kumar Sen, Professor Emeritus, Jadavpur University in whose honour this volume has been prepared was one of the leading philosophers of our country and a highly respected teacher. It carries thirty-five articles which deal with different branches of philosophy,viz., philosophical logic, philosophy of language, ontology, theory of knowledge, Kant exegesis, moral philosophy, social philosophy, philosophy of art. As Sen's philosophical interests and expertise were wide the authors had ample freedom in their choice of topics. (...) This volume will be of interest to those who are acquainted with sophisticated literature in analytic philosophy, scholars working in different branches of philosophy and also general readers of modern philosophy. (shrink)

If we consider modeling not as a heap of contingent structures, but (where possible) as evolving coordinated systems of models, then we can reasonably explain as "direct representations" even some very complicated model-based cognitive situations. Scientific modeling is not as indirect as it may seem. "Direct theorizing" comes later, as the result of a successful model evolution.

This book develops some of the most important themes of Sen's works over the last decade. He argues in a rich and subtle approach that we should be concerned with people's capabilities rather than their resources or welfare.

Gary Becker and others have done important work to broaden the content of self interest, but have not departed from seeing rationality in terms of the exclusive pursuit of self-interest. One reason why committed behavior is important is that a person can have good reason to pursue objectives other than self interest maximization (no matter how broadly it is construed). Indeed, one can also follow rules of behavior that go beyond the pursuit of one's own goals, even if the goals (...) include non-self-interested concerns. By living in a society, one develops possible reasons for considering other people's goals as well, which takes one beyond an exclusive concentration on one's own goals, not to mention the single-minded pursuit of one's own self interest. The recognition of other people's goals may be a part of rational thought. If rational behavior may depart from the relentless pursuit of one's own goals, commitment has to be important in a theory of rationality. Furthermore, seeing the role of commitment in human behavior can have explanatory importance in allowing us to understand behavior patterns that are hard to fit into the narrow format of contemporary rational choice theory. Commitment is, thus, important both for practical reason and for causal explanation. (shrink)

How valuable is the market mechanism for practical morality? What is its moral standing? We can scarcely doubt that as individuals we do value tremendously the opportunity of using markets. Indeed, without access to markets most of us would perish, since we don't typically produce the things that we need to survive. If we could somehow survive without using markets at all, our quality of life would be rather abysmal. It is natural to feel that an institution that is so (...) crucial to our well-being must be valuable. And since moral evaluation can hardly be indifferent to our interests and their fulfillment, it might appear that there is nothing much to discuss here. The market's moral standing “has to be” high. (shrink)

In the summer of 1997, I was asked by a leading Japanese newspaper what I thought was the most important thing that had happened in the twentieth century. I found this to be an unusually thought-provoking question, since so many things of gravity have happened over the last hundred years. The European empires, especially the British and French ones that had so dominated the nineteenth century, came to an end. We witnessed two world wars. We saw the rise and fall (...) of fascism and Nazism. The century witnessed the rise of communism, and its fall (as in the former Soviet bloc) or radical transformation (as in China). We also saw a shift from the economic dominance of the West to a new economic balance much more dominated by Japan and East and Southeast Asia. Even though that region is going through some financial and economic problems right now, this is not going to nullify the shift in the balance of the world economy that has occurred over many decades (in the case of Japan, through nearly the entire century). The past hundred years are not lacking in important events. (shrink)

We examined proactive and reactive control effects in the context of task-relevant happy, sad, and angry facial expressions on a face-word Stroop task. Participants identified the emotion expressed by a face that contained a congruent or incongruent emotional word. Proactive control effects were measured in terms of the reduction in Stroop interference as a function of previous trial emotion and previous trial congruence. Reactive control effects were measured in terms of the reduction in Stroop interference as a function of current (...) trial emotion and previous trial congruence. Previous trial negative emotions exert greater influence on proactive control than the positive emotion. Sad faces in the previous trial resulted in greater reduction in the Stroop interference for happy faces in the current trial. However, current trial angry faces showed stronger adaptation effects compared to happy faces. Thus, both proactive and reactive control mechanisms are dependent on emotional valence of task-relevant stimuli. (shrink)

This paper is about three distinct but interrelated problems: (1) the role 0f rights in moral theory, (2) thc characterization 0f agent relative values and their admissibility in consequ<—:ncc—bascd evaluation, and ( 3) the nature 0f moral evaluation 0f states 0f aihirs.

Interdisciplinary research needs innovation. As an action-oriented intervention, this Manifesto begins from the authors’ experiences as social scientists working within interdisciplinary science and technology collaborations in agriculture and food. We draw from these experiences to: 1) explain what social scientists contribute to interdisciplinary agri-food tech collaborations; (2) describe barriers to substantive and meaningful collaboration; and (3) propose ways to overcome these barriers. We encourage funding bodies to develop mechanisms that ensure funded projects respect the integrity of social science expertise and (...) incorporate its insights. We also call for the integration of social scientific questions and methods in interdisciplinary projects from the outset, and for a genuine curiosity on the part of STEM and social science researchers alike about the knowledge and skills each of us has to offer. We contend that cultivating such integration and curiosity within interdisciplinary collaborations will make them more enriching for all researchers involved, and more likely to generate socially beneficial outcomes. (shrink)